{"id":642,"date":"2020-05-19T13:43:25","date_gmt":"2020-05-19T11:43:25","guid":{"rendered":"https:\/\/cbchealth.de\/?page_id=642"},"modified":"2020-08-07T16:31:57","modified_gmt":"2020-08-07T14:31:57","slug":"cord-blood-relevant-clinical-trials","status":"publish","type":"page","link":"https:\/\/cbchealth.de\/en\/cord-blood-relevant-clinical-trials\/","title":{"rendered":"Clinical trials"},"content":{"rendered":"

Results of several clinical trials(1-9)<\/sup>\u00a0studying \u00a0the cord blood cell intravenous infusion treatment of ischemic stroke have been published in scientific literature since 2012. The effect of the treatment has been studied mostly on children with cerebral palsy(1,2,3,5,6,7,8)<\/sup>\u00a0in majority caused by ischemic stroke during labor and delivery. One study has been conducted on adult patients after ischemic stroke(4)<\/sup>. Some studies have used autologous cord blood(3,7,8)<\/sup>, others have used allogeneic cord blood(1,2,4,5,6,9)<\/sup>. All have shown trend or significant improvement in motoric and cognitive functions of the patients.<\/p>\n

One study has shown clinical improvement after repetitive treatment 3-6 and 6-12 months after the first treatment(6)<\/sup>.<\/p>\n

In Most of the studies patients have undergone the treatment several years after the ischemic stroke event(1,2,3,4,6,7,8,9)<\/sup>. The only study conducted on adults has included patients up to 10 days after the ischemic stroke event(4)<\/sup>.<\/div>\n

Clinical Trials:<\/strong><\/p>\n

\n1. Feng, Mei et al. \u201cSafety of Allogeneic Umbilical Cord Blood Stem Cells Therapy in Patients with Severe Cerebral Palsy: A Retrospective Study.\u201d Stem cells international vol. 2015 (2015): 325652. doi:10.1155\/2015\/325652
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4510256\/<\/a><\/p>\n

2. Kang, Mino et al. \u201cInvolvement Of Immune Responses In The Efficacy Of Cord Blood Cell Therapy For Cerebral Palsy.\u201d Stem Cells and Development 24.19 (2015): 2259-2268. Web.
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Involvement+of+Immune+Responses+in+the+Efficacy+of+Cord+Blood+Cell+Therapy+for+Cerebral+Palsy<\/a><\/p>\n

3. Lee, Young-Ho et al. \u201cSafety and feasibility of countering neurological impairment by intravenous administration of autologous cord blood in cerebral palsy.\u201d Journal of translational medicine vol. 10 58. 23 Mar. 2012, doi:10.1186\/1479-5876-10-58
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3369209\/<\/a><\/p>\n

4. Laskowitz, Daniel T. et al. \u201cAllogeneic Umbilical Cord Blood Infusion For Adults With Ischemic Stroke: Clinical Outcomes From A Phase I Safety Study\u201d. STEM CELLS Translational Medicine, vol 7, no. 7, 2018, pp. 521-529. Wiley, doi:10.1002\/sctm.18-0008.
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Allogeneic+Umbilical+Cord+Blood+Infusion+for+Adults+with+Ischemic+Stroke%3A+Clinical+Outcomes+from+a+Phase+1+Safety+Study<\/a><\/p>\n

5. Min, Kyunghoon et al. \u201cUmbilical cord blood therapy potentiated with erythropoietin for children with cerebral palsy: a double-blind, randomized, placebo-controlled trial.\u201d Stem cells (Dayton, Ohio) vol. 31,3 (2013): 581-91. doi:10.1002\/stem.1304
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3744768\/<\/a><\/p>\n

6. Romanov, Yury A. et al. \u201cHuman Allogeneic AB0\/Rh-Identical Umbilical Cord Blood Cells In The Treatment Of Juvenile Patients With Cerebral Palsy.\u201d Cytotherapy 17.7 (2015): 969-978. Web.
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Human+allogeneic+AB0%2FRh-identical+umbilical+cord+blood+cells+in+the+treatment+of+juvenile+patients<\/a><\/p>\n

7. Sun, Jessica et al. \u201cAutologous Cord Blood Infusion For The Treatment Of Brain Injury In Children With Cerebral Palsy.\u201d Blood 126.23 (2015): 925-925. Web.
\nhttp:\/\/www.bloodjournal.org\/content\/126\/23\/925?sso-checked=true<\/a><\/p>\n

8. Sun, Jessica M. et al. \u201cEffect Of Autologous Cord Blood Infusion On Motor Function And Brain Connectivity In Young Children With Cerebral Palsy: A Randomized, Placebo-Controlled Trial.\u201d STEM CELLS Translational Medicine 6.12 (2017): 2071-2078. Web.
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Effect+of+Autologous+Cord+Blood+Infusion+on+Motor+Function+and+Brain+Connectivity+in+Young+Children+with+Cerebral+Palsy%3A+A+Randomized%2C+Placebo-Controlled+Trial<\/a><\/p>\n

9. Ying, L. \u201cSafety Analysis Of Umbilical Cord Blood Stem Cell Transplantation Combined With Nerve Growth Factor In The Treatment Of Cerebral Palsy In Children.\u201d Chinese Journal of Tissue Engineering Research (2014): n. pag. Print. (link unavailable)\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Results of several clinical trials(1-9)\u00a0studying \u00a0the cord blood cell intravenous infusion treatment of ischemic stroke have been published in scientific literature since 2012. The effect of the treatment has been studied mostly on children with cerebral palsy(1,2,3,5,6,7,8)\u00a0in majority caused by ischemic stroke during labor and delivery. One study has been conducted on adult patients after […]<\/p>\n","protected":false},"author":57,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-content.php","meta":{"footnotes":""},"class_list":["post-642","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/cbchealth.de\/en\/wp-json\/wp\/v2\/pages\/642","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cbchealth.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cbchealth.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cbchealth.de\/en\/wp-json\/wp\/v2\/users\/57"}],"replies":[{"embeddable":true,"href":"https:\/\/cbchealth.de\/en\/wp-json\/wp\/v2\/comments?post=642"}],"version-history":[{"count":3,"href":"https:\/\/cbchealth.de\/en\/wp-json\/wp\/v2\/pages\/642\/revisions"}],"predecessor-version":[{"id":689,"href":"https:\/\/cbchealth.de\/en\/wp-json\/wp\/v2\/pages\/642\/revisions\/689"}],"wp:attachment":[{"href":"https:\/\/cbchealth.de\/en\/wp-json\/wp\/v2\/media?parent=642"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}